Following are rough look angles and times based upon a 1:38 AM EDT splashdown in the Tampa recovery area (See circle to the west/left of Tampa Florida).

Start of fiery re-entry: 1:25 AM EDT (12:25 AM CDT)
End of fiery re-entry: 1:32 AM EDT (12:32 AM CDT)
Splashdown: 1:38 AM EDT (12:38 AM CDT)
I would be in my observing spot at least ten minutes early.
1) Key West/southern Florida: Southwest to northwest. Possibly too far away.
2) Tampa: Southwest to west-southwest. Highest elevation is probably from this area
3) Beach south of Tallahassee: South-southwest to south. Close to horizon
4) Panama City: South to southeast Possibly near limit of seeing it.
5) Gulfport MS to New Orleans: Southeast. Likely too far away
If you look at the distance of the Tampa recovery area to the beach just south of Tallahassee, CRS-21 was seen low (close to the horizon) on CRS-21 (See photo below). A similar distance or even further in a circle around the end of the fiery re-entry phase has the potential of seeing it. I would scan left and right of these directions and from the horizon up 20 degrees or so (perhaps higher near Tampa). I won't guarantee visibility but it may be seen east and south of Tampa . Orlando? Unknown.
I did see one re-entry photo taken from New Orleans but it may have been to a closer recovery area than Tampa. This event may not be visible from the more western and southern locations listed above.
I have only seen one re-entry (Crew-7) and it was easy to spot at night. Binoculars were not needed to initially see it.
CRS-21 as seen from Shell Point beach south of Tallahassee: