The Human Research Program (HRP) has assigned the Exploration Medical Capabilities (ExMC) element the responsibility of addressing the overarching risk of the inability to adequately treat an ill or injured crewmember. The Space Medicine Exploration Medical Condition List (SMEMCL) was created in order to define the set of medical conditions that are most likely to occur during any one of seven distinct mission profiles, as the first step in addressing the above mentioned risk. The list was derived from the International Space Station (ISS) medical checklist, the Space Shuttle (STS) medical checklist, Longitudinal Study of Astronaut Health (LSAH) in-flight occurrence data, and the Delphi study, and assumes use of the new Crew Exploration Vehicle (CEV). The list of conditions was further prioritized for the seven specific missions with the assistance of the ExMC Advisory Group, which included flight surgeons and representatives from the astronaut office, Space Medicine Division management, and the National Space Biomedical Research Institute. http://ntrs.nasa.gov/archive/nasa/casi.ntrs.nasa.gov/20100014348_2010013906.pdf