I'M COPYING THIS RESPONSE I GAVE TO A QUESTION IN ANOTHR THREAD HERE FOR BETTER VISIBILITY SINCE THERE IS SO MUCH DISCUSSION OF THE FREON LOOP FLEX HOSE ISSUE FOR STS-122.
pcb_man - 31/1/2008 1:08 PM
I'm guessing that the Freon loops are in ISO during launch, and only activated after PLB doors are open, correct?

Space Shuttle Thermal Control 101:
"Depending on the mission phase, the Freon cooling loops are cooled four different ways. Prior to launch, cooling is provided by way of the Ground Support Equipment (GSE). After lift-off, there is no active means of cooling until after SRB SEP. It takes the orbiter slightly more than 2 minutes to reach an altitude where water evaporation provides effective cooling (i.e. FES). Until that time, sufficient “thermal inertia’’ is in the Freon loops to limit the temperature increase so that no active heat rejection is required.
At SRB SEP, the FES (flash evaporator system) receives a GPC (general purpose computer) “ON” command from the BFS (backup flight system) and begins providing active cooling. The FES continues to be the primary cooling source through the ascent phase and on into the post insertion timeframe. During the Post Insertion Checklist procedures, flow is initiated through the radiators, the payload bay doors are opened, and the radiators become the primary source of cooling. The FES may be left on to provide supplemental cooling when necessary. If the orbiter is in a warm attitude, radiator cooling efficiency may decrease and the FES may be needed to provide additional cooling to achieve the desired Freon loop temperatures.
During the deorbit prep procedures, the radiators are “coldsoaked” to provide cooling for use
later during entry. The radiator coldsoak process lowers the temperature of Freon in the radiators by changing the radiator control temperature from 38° F to 57° F. Since less cool Freon from the radiators is required to control to this high temperature, flow through the radiators is slower. As a result, the Freon spends a longer period in the radiators exposed to space and becomes colder than if the flow control valve were controlling for a 38° F radiator out temperature. The FES is used to cool the Freon from 57° F to 39° F. After approximately 1 hour of coldsoak, the radiators are bypassed, trapping the cold Freon in the radiators. At this point, the FES providesall the cooling to the Freon loops. The FES supplies cooling during the rest of the deorbit, through EI (entry interface @ 400,000 feet), and down to V = 12k (approximately 175,000 feet).
At V = 12k (velocity of 12,000 feet per second), the radiators are activated, since below 100,000 ft the atmospheric pressure is too high for the FES to cool effectively. Radiator flow is reinitiated after the auto startup sequence is complete. The cool Freon stored in the radiators is used as the primary source of cooling from this point through rollout.
Once the orbiter is on the ground and the radiator coldsoak is depleted, the NH3 (ammonia) boiler is activated. The MCC (mission control center) calls the crew to request the NH3 activation. The NH3 boilers are used as the primary cooling source until the GSE cooling cart hookup is complete. Then the NH3 cooling is deactivated, and GSE cooling is initiated."
One of the real concerns with this issue is not just that some freon might leak out, rather the concern is the potential for a loss of cooling capability. The orbiter can work on a single loop just fine, however, there will likely be an increased use of water for the FES and a need for possible electrical power downs - this is dependent on current orbiter heat loads. You definitely don't like to be down to one loop because of the loss of redundancy. If both loops were to be lossed while on orbit you would need to come home quickly (i.e. De-Orbit as soon as possible and land at the next PLS - primary landing site).
Mark Kirkman