Lets assume that all autopilot systems would fail on a reentry to earth:
Do you know if the pilots could fly the shuttle back to SLF (RWY) including all rolls/roll-reversals, HDG-, AOA-, ALT-changes by manual inputs only by looking at their CRTs etc...?
Would this be possible...?
Thanks very much! 
Kind regards
Susan
Any and all portions of a Space Shuttle Entry can be flown manually if necessary and the astronauts are thoroughly trained for this.
The real question would be what is the nature of the failure?
All of the information that the crew would use is displayed on both the GPC (general purpose computer) CRTs and the Primary Flight Displays/Dedicated Displays (ADI, HIS, Alpha, Mach, etc.). This information is supplied by software modules within the GPCs (specifically Guidance and Navigation) and this data is derived from various sensors such as the inertial measurement units, accelerometer assemblies, GPS, TACAN, air data probes, microwave landing system, radar altimeters etc. That data is then used by either the DAP (digital auto pilot) or the Astronauts to control the orbiter during Entry and Landing.
Depending on what type of failures occur within Guidance or NAV (or even within the BFS verses the PASS) it may still be possible for either auto flight control or Crew inputs (which are directed thru the DAP) to fly the orbiter safely to a runway, or worst case scenario, to a stable bailout condition. There are also specific failures within the flight control module itself that would require the crew to takeover and fly the Entry manually. All of the takeover criteria are clearly defined (most are listed within the Flight Rules) and the astronauts are trained to act based on the circumstances.
So to answer your specific question; yes the crew can fly manually – using heading, alpha (angle of attack), drag altitude, airspeed/mach, etc. The piloting task would include roll reversals just like an auto entry. All of this of course is dependent on the nature of the original failure.
Mark Kirkman
P.S.
A key point I forgot to make in my post is that even manual inputs by the crew are directed thru the DAP which means some DAP failures take out both auto and manual flight control. Such failures would be many levels deep however.