Ignition is basically impossible in a non-pressurized volume. Any gas dissipates at approximately the speed of sound into the vacuum of space, so you’ll not have enough gas around. Additionally, you need BOTH fuel and oxidizer to get combustion in space. This is one way where refueling in space is actually easier than on the ground where there’s ambient pressure and the atmosphere already has oxygen in it, so oxygen alone is sufficient.The materials science of sealing isn’t really any harder than on the ground (vacuum welding is a thing, but it’s actually rare for this to happen). But there’s additional advantages in that you don’t have to worry about ice (or even liquefied air) condensation, which at cryogenic temperatures is as strong as like epoxy. On the ground, condensation and frost can build up which interferes with a seal or makes it difficult to disengage. Not so in vacuum.
Ignition is basically impossible in a non-pressurized volume. Any gas dissipates at approximately the speed of sound into the vacuum of space, so you’ll not have enough gas around.